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Journal: bioRxiv
Article Title: Modulating Cardiac-Gut Microbiome Interaction Post-Myocardial Infarction with Engineered Bacteria
doi: 10.1101/2025.07.10.664025
Figure Lengend Snippet: (A) Relative frequency bar chart shows anaerobic classes such as Bacteroidia, Clostridia, and Verrumicrobiaie to be the prominent colonizers of the MI heart, (B) Taxonomic Cladogram from LEfSe showing taxonomic association between MI heart, intestinal, and fecal microbiome samples, (C) Relative abundance of the different microbial classes across MI hearts, intestines, and feces, (D-E) Mantel test analyses of unweighted and weighted UniFrac shows significant correlation in paired samples of MI hearts and intestines (Spearman’s rho (r s )=0.54, p=0.031 for unweighted UniFrac; r s =0.53, p=0.035 for weighted UniFrac), (F-G) Mantel test analyses of unweighted and weighted UniFrac shows significant correlation in paired samples of MI hearts and feces (r s =0.56, p=0.018 for unweighted UniFrac; r s =0.63, p=0.03 for weighted UniFrac), (H) PCR for 16S rRNA gene in pig hearts reveals presence of bacteria in ischemic hearts, but not naïve hearts.
Article Snippet: The V4 hypervariable region of the
Techniques: Bacteria